Equipment

Circadian / Metabolic Activity
Contextual Fear Conditioning
Elevated Plus Maze
Forced Swim Test
Open Field Activity Test
Operant Conditioning
Rotarod Test
Social Interaction Test
Startle Sensitivity / Pre-Pulse Inhibition
Treadmill - Gait/Stride Test
Y-Maze Spontaneous Alternation Test

Circadian / Metabolic Activity

circadian metabolic activity

Monitoring animals in a familiar environment for long periods of time is necessary to detect any alteration in activity levels, feeding, drinking, and gas exchange (metabolic) rates across light/dark phases.  The apparatus is a set of Oxymax Metabolic Activity Monitoring chambers (CLAMS, Columbus Instruments).

Contextual Fear Conditioning

Contextual Fear Conditioning

Monitoring animals in a familiar environment for long periods of time is necessary to detect any alteration in activity levels, feeding, drinking, and gas exchange (metabolic) rates across light/dark phases.  The apparatus is a set of Oxymax Metabolic Activity Monitoring chambers (CLAMS, Columbus Instruments).

Elevated Plus Maze

Elevated Plus Maze

This test is used to assess anxiety-like behaviors in mice.The apparatus comprises two open arms and two enclosed arms. All four arms have an open roof and extend from a common central platform. The test consists of a single session.

Forced Swim Test

Forced Swim Test

This procedure is used to induce a despair-like state and to explore the effects of antidepressants in mice.

Open Field Activity Test

Open Field Activity Test

The open field test is used to study behavioral responses in mice confined to a novel arena. This test can be used to measure both genotype and/or drug induced changes in locomotor activity, anxiety, and context habituation.

Operant Conditioning

Operant Conditioning

Several operant paradigms are used to assess different aspects of cognition, i.e. procedural learning (continuous reinforcement), extinction learning (lever-press extinction), visual discrimination learning (light-lever pairing discrimination), and attention (2-choice serial reaction time).

Rotarod Test

Rotarod Test

The purpose of the Rotarod test is to assess the mouse's sensorimotor coordination and/or fatigue resistance. The Rotarod apparatus (Stoelting; UgoBasile Apparatus) consists of a rod that is capable of rotating at different speeds. During test trials the rod revolves with a steady rate of acceleration from 4 – 40 rpm over a 5-minute period.

Social Interaction Test

Social Interaction Test

This test is used to assess aspects of sociability, preference for social novelty and/or social recognition memory performance in mice.

Startle Sensitivity / Pre-Pulse Inhibition

Startle Sensitivity / Pre-Pulse Inhibition

Acoustic startle reflex is a natural response to strong exteroceptive stimuli. It is widely used to assess sensorimotor reactivity and gaiting in rodents. Pre-Pulse Inhibition (PPI) refers to the reducing effect of a weak (non-startling) pre-stimulus on the subsequent startling effect of an intense stimulus.

Treadmill - Gait/Stride Test

 Treadmill - Gait/Stride TestTreadmill - Gait/Stride Test

The use of a treadmill is a convenient and sensitive method to evaluate motor performance and motor coordination in mice. Combined to a sensitive video-tracking system, it also allows gathering data for gait/stride analysis.

Y-Maze Spontaneous Alternation Test

 Y-Maze Spontaneous Alternation Test

This test is used to assess spatial working memory performance; it is based on theThe apparatus is a Plexiglas Y-shaped maze consisting of 3 equidistant arms. The test consists of a single session. The distance traveled and the sequences of arm entries during testing are automatically recorded by the CleverSys computer-assisted video-tracking system.