2014 Competition
7 proposals selected for funding by the review committee:
Tao Ho Lee (BIDMC) — Role of DAPK1 on Tau and Amyloid Pathogenesis
Iman Aganj (MGH) — Connectomic Biomarkers of Alzheimer's Disease Observed in Multi-Synaptic Pathways
Martin Reuter (MGH) — Longitudinal Shape & Morph Analysis for High-Sensitivity Detection of Surrogate Biomarkers in Neurodegenerative Disease
Wasim Malik (MGH) — Multiscale Decoding in Neural Prosthetics for ALS Rehabilitation
Susan Frost (BWH) — Investigating lamin dysfunction as a novel mechanism of tau neurotoxicity
Roopali Gandhi (BWH) — Functional Relevance of miR-92a in Multiple Sclerosis
John Yoon (BWH) — Roles of secreted factors in neurodegeneration associated with Leigh syndrome
2013 Competition
8 proposals selected for funding by the review committee:
Zara Herskovits (BWH) — CSF Biomarkers for ALS
Robin Reed (HMS) — High Throughput Screen to Identify ALS Drug Candidates
Elena Ratti (MGH) — Longitudinal Characterization of the FTD-ALS Spectrum
Wassim Elyaman (BWH) — Identification of Small Molecules that Target Memory T Cells for MS Therapeutics
Paul Rosenberg (BCH) — Abnormal Integrated Stress Response in HD
Vikram Khurana (MGH) — A Comprehensive Stem Cell-Based Screening Platform for Synucleiopathy
Julius Hedden (MGH) — Cognitive Profiles of Imaging Biomarkers in Preclinical AD
Stephen Gomperts (MGH) — Impairment in the Ensemble Representation of Space and Memory in a Mouse Model of AD
2012 Competition
11 proposals selected for funding by the review committee:
Katherina Cosker (DFCI) — A role for Bclw in neurotrophin-dependent prevention of axonal degeneration
Brian Wainger (CHB) — Electrophysiological characterization of ALS patient-derived motor neurons
Jacob Hooker (MGH) — Combined FDG-PET and MRI in early ALS
David Livingston (DFCI) — Is excessive R loop-driven DNA damage a component of ALS pathogenesis?
Teresia Osborn (McL) — Preclinical studies of guanine deaminase as a protector of ALS-related motor neuron death
Shaomin Li (BWH) — Enriched environment prevents AB-impaired LTP viathe B-adrenoceptor signaling pathway
Gabriel Corfas (CHB) — Exploring the links between AD and ErbB4 nuclear signaling
Elizabeth Bradshaw (BWH) — Functional significance of CD33 surface density and its implications for AD susceptibility
Christopher William (MGH) — Synaptic plasticity in Down Syndrome
Tim Bartels (BWH) — Impact of N-terminal acetylation on folding and lipid interaction of alpha-synuclein
Robert Ellis (BIDMC) — Neural mechanisms of motor timing in PD
2011 Pilot Studies
Min Liu (BWH) — Understanding the Mechanism of Regulating LRRK2 Functions
Pamela McLean (MGH) — Alpha-Synuclein in Exosomes from Human CSF and Brain in Parkinson's
Nazem Atassi (MGH) — Mechanism-Based Neuroimaging in ALS
Tracy Young-Pearse (BWH) — Patient-derived iPSCs to Address Mechanisms of Alzheimers Disease
Joshua Shulman (BWH) — Functional Validation of Alzheimer's Genome-wide Association Signals
John Becker (MGH) — Longitudinal Modeling of Dynamic Biomarkers of the AD Pathologic Cascade
2010 Pilot Studies
Ciprian Catana (MGH) — Identification of Potential Compensatory Mechanisms in Alzheimer's Disease by Accurate Structure-Function Inter-Relation Using Simultaneous MR-PET Technology
M. Teresa Gomez-Isla (MGH) — Are Some Human Brains Able to Tolerate the Insult of Aß?
Min Jeong Kye (CHB) — Exploring the Role of SMN in miRNA in Axons
Catherine Stamoulis (BIDMC) — Detection of Copy Number Changes in DNA of Patients with Sporadic ALS
Jaehong Suh (MGH) — Transgenic Mouse Study of Novel ADAM10 Mutations in Alzheimer's Disease
Martin Can Zhang (MGH) — Characterizing a Novel AD GWAS Gene: ATXN1
2009 Pilot Studies
Sydney S. Cash (MGH) — Subclinical Paroxysmal EEG Abnormalities in Alzheimer’s Disease
David Greer (MGH) — Effect of Cerebral Hypoperfusion on B-Amyloid Deposition
Guo-Fu Hu (HMS) — Stress-Induced Small RNAs in Neuron Survival
Nikolaus McFarland (MGH) — Examination of Brain Urate Metabolites in Neurodegenerative Disease
Scott McGinnis (MGH) — Application of Ultrahigh Resolution MRI to Develop Imaging Biomarkers in Frontotemporal Lobar Degeneration
Jacob Sloane (BIDMC) — Identifying Proteins Associated with Impaired Remyelination and with Cortical Lesions in Multiple Sclerosis
Ottavio Vitolo (HMS) — Memory Network Dysfunction in Patients with Late Life Depression
2008 Pilot Studies
Mark Albers (MGH) — Is the map of axon projections from human olfactory sensory neurons into the olfactory bulb disrupted in AD patients?
Paola Arlotta (MGH) — Induction of corticospinal motor neuron specifications by cellautonomous transcription factor signaling
Susan Cotman (MGH) — Investigating accumulation of themitochondrial atpase subunit c protein as a marker for autophagydysfunction in neurodegenerative disease
Stefanie Freeman (MGH) - Pathologic phenotypes of Alzheimer's disease
Sang-Jun Jeon (MEEI) - Small molecules for regeneration of hair cells
Volney Sheen (BIDMC) — Mitochondrial dysfunction from astroglial S100B in human DS neural progenitors
Kai Sonntag (McLean) — Regulation of gene expression in dopamine neurons by miRNAs
Anand Viswanathan (MGH) — Cortical morphological consequences of subcortical vascular pathology in cerebral amyloid angiopathy
2007 Pilot Studies
Christopher Gibbons (Roy Freeman) (BIDMC) — A human model of autonomic nerve fiber degeneration and regeneration
Steven Hersch (MGH) — Surrogate marker of therapeutic response in Huntington’s disease
Fuxin Shi (Albert Edge) (MEEI) — Replacement of auditory neurons to enhance the function of a cochlear implant
Olivia Okereke (Deborah Blacker) (MGH) — Pilot study for development of a shortened clinical dementia rating questionnaire
Daniel Press (BIDMC) — Genotype-phenotype relations underlying cognitive dysfunction in Parkinson’s disease
Eric Smith (MGH) — Pittsburgh compound-B imaging and subcortical small vessel damage
2006 Pilot Studies
Brandon Ally (BWH) — P50 as a measure of cholinergic response in Alzheimer's disease
Phil de Jager (BWH) — Developing an immunoprofile into a diagnostic tool for multiple sclerosis
Allitia DiBernardo (MGH) — Open-label, dose-escalating clinical trial of high-dose creatine in patients with amyotrophic lateral sclerosis
Florian Eichler (MGH) — Immunomodulatory therapy in X-linked adrenolukodystrophy
Stephen Gomperts (MGH) — Alpha-synuclein measurement and molecular imaging in Parkinson's disease dementia
Christopher Holland (BWH) — Evaluating continuous arterial spinlabeling in the investigation of the role of perfusion in the evolutionand repair of white matter lesions in multiple sclerosis
Lisa Krivickas (Spaulding) — Motor unit behavior in amyotrophic lateral sclerosis
2005 Pilot Studies
James Beck (Mass Mental Health Hospital) — Neuregulin 1 and Schizophrenia Phenotype
Joan Camprodon (BIDMC) — Stroke Repair and NeglectRecovery: An fMRI Study Assessing Physiopathologic Mechanisms and TMSApplications for Rehabilitation Therapy
Michael Irizarry (MGH) — High Dose Multivitamin Treatment: Effect on Plasma A-Beta and White Matter Lesions in the VISP study
Rachel Nardin (BIDMC) — Diaphragm Training in Amyotrophic Lateral Sclerosis
David Wolk (BWH) — ERP Correlates of Encoding and Retrieval in Mild Cognitive Impairment and Alzheimer's Disease
2004 Pilot Studies
Paolo Bonato (Spaulding Rehabilitation Hospital) — Enhancing DBS parameter adjustment through measures of motor response
Andrew Budson (BWH) — Using false recognition as an outcome measure for clinical trials
Gregory Esper (BIDMC) — Assessment of neuromuscular disease using multifrequency-dependent electrical impedance myography
Dominik Meier (BWH) — Capturing short term disease activity in MS
Magdy Selim (BIDMC) — A pilot study to evaluate the safety and tolerability of iron chelator, deferoxamine, in elderly stroke patient